Journal of Medicinal and Chemical Sciences

Tactics of Treatment of Catastrophic Anti-Phospholipid Syndrome in Pregnant Woman: Based on a Clinical Case

Nataliya Tytarenko; Inna Kukuruza; Olga Zasadnіuk; Andriy Kostyuchenko; Andrii Vozniuk

Volume 6, Issue 11 , November 2023, , Pages 2569-2579

https://doi.org/10.26655/JMCHEMSCI.2023.11.1

Abstract

Objective: The objective of this study is to investigate the occurrence and management of acute thrombotic microangiopathy, a severe complication associated with antiphospholipid syndrome ... Read More Objective: The objective of this study is to investigate the occurrence and management of acute thrombotic microangiopathy, a severe complication associated with antiphospholipid syndrome (APS), particularly in the context of catastrophic APS (CAPS) during pregnancy. The study aims to enhance the understanding of CAPS in pregnancy, improve early diagnosis, and evaluate the effectiveness of different treatment modalities.Materials and methods: The study employed a case report methodology, focusing on a pregnant patient diagnosed with CAPS and experiencing acute thrombotic microangiopathy. The clinical presentation, laboratory findings, diagnostic procedures, and treatment interventions were documented and analysed. The treatment approach included the use of anticoagulants, glucocorticoids, and plasma exchange. The response to treatment, complications, and patient outcomes were assessed.Results: The study observed a rapid development of liver, central nervous system, and renal lesions within a week, indicating the severity of CAPS in the pregnant patient. Despite the pregnancy termination, the patient's clinical condition did not show improvement, suggesting a lack of response similar to observations in other cases. The patient received standard CAPS treatment, except for intravenous administration of immunoglobulins. Further details were reported regarding the treatment outcomes, laboratory parameters, and imaging findings.Conclusion: This study highlights the challenges associated with diagnosing and managing CAPS during pregnancy, specifically focusing on acute thrombotic microangiopathy. Early diagnosis, aggressive treatment with anticoagulants and glucocorticoids, and the use of plasma exchange or intravenous immunoglobulin are crucial in achieving positive outcomes. The study suggests the consideration of alternative interventions, such as immunosuppressive therapy or targeted biologic agents, in refractory cases of CAPS. Further research is needed to elucidate the optimal treatment strategies and long-term outcomes in pregnant patients with CAPS.

Symptoms of Acute and Chronic Viral Hepatitis: Effects on Human Body

Marko Kozyk; Kateryna Strubchevska; Vitalina Yuzkiv; Ulyna Bezkorovayna; Roksolana Nedilko

Volume 6, Issue 11 , November 2023, , Pages 2580-2587

https://doi.org/10.26655/JMCHEMSCI.2023.11.2

Abstract

Objective: The objective of this article is to study the theoretical and applied principles of the symptoms of acute and chronic viral hepatitis and the consequences of their impact ... Read More

Emergency Medical Care Functioning During COVID-19 Pandemic in Eastern Europe

Oleksandr Knigavko; Nadiia Baranova; Ievgen Bausov; Maryna Dolzhenko; Nataliia Lantukhova

Volume 6, Issue 11 , November 2023, , Pages 2588-2599

https://doi.org/10.26655/JMCHEMSCI.2023.11.3

Abstract

Objective: The objective of this study is to examine the challenges faced by treatment organizations and assess the current state of emergency medical care facilities in Poland and ... Read More

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Author = Kozyk, Marko

Tactics of Treatment of Catastrophic Anti-Phospholipid Syndrome in Pregnant Woman: Based on a Clinical Case

Abstract

Symptoms of Acute and Chronic Viral Hepatitis: Effects on Human Body

Abstract

Emergency Medical Care Functioning During COVID-19 Pandemic in Eastern Europe

Abstract